Retinal Cell Biology

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Retinal Cell Biology April 2018

Topical Ripasudil Suppresses Retinal Ganglion Cell Death in a Mouse Model of Normal Tension Glaucoma

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Kei Akaiwa; Kazuhiko Namekata; Yuriko Azuchi; Hiroki Sano; Xiaoli Guo; Atsuko Kimura; Chikako Harada; Yoshinori Mitamura; Takayuki Harada
TAGS: mice, glaucoma, normal-tension, neuroprotection, retinal ganglion cells
Invest. Ophthalmol. Vis. Sci.. 2018; 59(5):2080-2089. doi: 10.1167/iovs.17-23276

Retinal Cell Biology April 2018

Photoreceptor Cell–Derived CAPN5 Regulates Retinal Pigment Epithelium Cell Proliferation Through Direct Regulation of SLIT2 Cleavage

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Yan Wang; Heming Li; Shihu Zang; Fanfan Li; Yingying Chen; Xiao Zhang; Zongming Song; Qing Peng; Feng Gu
TAGS: western blotting, mutation, cell proliferation, photoreceptors, antibodies, mice, proteins, cytokinesis, regulation, retinal pigment epithelium
Invest. Ophthalmol. Vis. Sci.. 2018; 59(5):1810-1821. doi: 10.1167/iovs.17-22689

Retinal Cell Biology March 2018

Dark Rearing Does Not Prevent Rod Oxidative Stress In Vivo in Pde6b rd10 Mice

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Bruce A. Berkowitz; Robert H. Podolsky; Ali M. Berri; Kristin Dernay; Emma Graffice; Fatema Shafie-Khorassani; Robin Roberts
TAGS: oxidative stress, magnetic resonance imaging, free radicals, rod photoreceptors, superoxides, mice
Invest. Ophthalmol. Vis. Sci.. 2018; 59(3):1659-1665. doi: 10.1167/iovs.17-22734

Retinal Cell Biology March 2018

Characterization of a Spontaneously Immortalized Murine Müller Glial Cell Line QMMuC-1

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Josy Augustine; Sofia Pavlou; Michael O'Hare; Kevin Harkin; Alan Stitt; Tim Curtis; Heping Xu; Mei Chen
TAGS: cytokine, glial fibrillary acidic protein, neuroglia, mice, glutamate
Invest. Ophthalmol. Vis. Sci.. 2018; 59(3):1666-1674. doi: 10.1167/iovs.17-23293

Retinal Cell Biology March 2018

Release of Different Cell Mediators During Retinal Pigment Epithelium Regeneration Following Selective Retina Therapy

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Elisabeth Richert; Stefan Koinzer; Jan Tode; Kerstin Schlott; Ralf Brinkmann; Jost Hillenkamp; Alexa Klettner; Johann Roider
TAGS: cytokine, vascular endothelial growth factor a, biological response modifiers, bodily secretions, cell size, culture media, fluorescent antibody technique, gelatinase a, ki-67 antigen, lasers, matrix metalloproteinases, choroid, retina, titration method, did not receive therapy or drug, retinal pigment epithelium, retinal pigment cell
Invest. Ophthalmol. Vis. Sci.. 2018; 59(3):1323-1331. doi: 10.1167/iovs.17-23163

Retinal Cell Biology March 2018

Metalloproteinase Adamts16 Is Required for Proper Closure of the Optic Fissure

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Mingzhe Cao; Jiamin Ouyang; Jingyi Guo; Siyuan Lin; Shuyi Chen
TAGS: phenotype, immunohistochemistry, basement membrane, bromodeoxyuridine, coloboma, embryo, genes, in situ nick-end labeling, metalloproteases, optics, zebrafish, eye, mice, rna, fissure
Invest. Ophthalmol. Vis. Sci.. 2018; 59(3):1167-1177. doi: 10.1167/iovs.17-22827

Includes: Supplemental Content

Retinal Cell Biology February 2018

Enteral Arg-Gln Dipeptide Administration Increases Retinal Docosahexaenoic Acid and Neuroprotectin D1 in a Murine Model of Retinopathy of Prematurity

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Lynn Calvin Shaw; Sergio Li Calzi; Nan Li; Leni Moldovan; Nilanjana Sengupta-Caballero; Judith Lindsey Quigley; Mircea Ivan; Bokkyoo Jun; Nicolas G. Bazan; Michael Edwin Boulton; Julia Busik; Josef Neu; Maria B. Grant
TAGS: dipeptides, docosahexaenoic acids, neovascularization, pathologic, retinopathy of prematurity, mice, injury of retina
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):858-869. doi: 10.1167/iovs.17-23034

Retinal Cell Biology February 2018

Endocan Blockade Suppresses Experimental Ocular Neovascularization in Mice

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Ting Su; Yisheng Zhong; Anna M. Demetriades; Jikui Shen; Ailing Sui; Yiyun Yao; Yushuo Gao; Yanji Zhu; Xi Shen; Bing Xie
TAGS: angiogenesis, vascular endothelial growth factor a, choroidal neovascularization, neovascularization, pathologic, mice
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):930-939. doi: 10.1167/iovs.17-22945

Includes: Supplemental Content

Retinal Cell Biology February 2018

Culture Systems of Dissociated Mouse and Human Pluripotent Stem Cell–Derived Retinal Ganglion Cells Purified by Two-Step Immunopanning

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Wataru Kobayashi; Akishi Onishi; Hung-Ya Tu; Yuji Takihara; Michiru Matsumura; Kazuko Tsujimoto; Masaru Inatani; Toru Nakazawa; Masayo Takahashi
TAGS: immunohistochemistry, organoids, retinal ganglion cells, mice, retina, stem cells, pluripotent, neuronal outgrowth
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):776-787. doi: 10.1167/iovs.17-22406

Includes: Supplemental Content

Retinal Cell Biology February 2018

Nanosecond Laser Treatment for Age-Related Macular Degeneration Does Not Induce Focal Vision Loss or New Vessel Growth in the Retina

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Kirstan A. Vessey; Tracy Ho; Andrew I. Jobling; Samuel A. Mills; Mai X. Tran; Alice Brandli; Jackson Lam; Robyn H. Guymer; Erica L. Fletcher
TAGS: blindness, lasers, age-related macular degeneration, mice, retina, laser therapy
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):731-745. doi: 10.1167/iovs.17-23098

Retinal Cell Biology February 2018

Effect of Anti-C5a Therapy in a Murine Model of Early/Intermediate Dry Age-Related Macular Degeneration

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Christopher B. Toomey; Michael Landowski; Mikael Klingeborn; Una Kelly; John Deans; Holly Dong; Ons Harrabi; Thomas Van Blarcom; Yik Andy Yeung; Ruslan Grishanin; John C. Lin; Daniel R. Saban; Catherine Bowes Rickman
TAGS: choroidal neovascularization, antibodies, choroid, age-related macular degeneration, mice
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):662-673. doi: 10.1167/iovs.17-23134

Includes: Supplemental Content

Retinal Cell Biology January 2018

Novel Animal Model of Crumbs-Dependent Progressive Retinal Degeneration That Targets Specific Cone Subtypes

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Jinling Fu; Mikiko Nagashima; Chuanyu Guo; Pamela A. Raymond; Xiangyun Wei
TAGS: burkina faso, retinal cone, animal model, photoreceptors, retinal degeneration, rod photoreceptors, ultraviolet rays, zebrafish, proteins, retina
Invest. Ophthalmol. Vis. Sci.. 2018; 59(1):505-518. doi: 10.1167/iovs.17-22572

Includes: Supplemental Content

Retinal Cell Biology January 2018

The Role of Angiotensin II/AT1 Receptor Signaling in Regulating Retinal Microglial Activation

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Joanna A. Phipps; Kirstan A. Vessey; Alice Brandli; Nupur Nag; Mai X. Tran; Andrew I. Jobling; Erica L. Fletcher
TAGS: signal transduction, angiotensin ii, microglia, eye, retina, intravitreal injections
Invest. Ophthalmol. Vis. Sci.. 2018; 59(1):487-498. doi: 10.1167/iovs.17-22416

Includes: Multimedia, Supplemental Content

Retinal Cell Biology December 2017

Crosstalk Between Histone and DNA Methylation in Regulation of Retinal Matrix Metalloproteinase-9 in Diabetes

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Arul J. Duraisamy; Manish Mishra; Renu A. Kowluru
TAGS: diabetes mellitus, diabetes mellitus, type 2, dna methylation, gelatinase b, histones, regulation, ezh2 gene
Invest. Ophthalmol. Vis. Sci.. 2017; 58(14):6440-6448. doi: 10.1167/iovs.17-22706

Retinal Cell Biology November 2017

Mast Cell-Derived Tryptase in Geographic Atrophy

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D. Scott McLeod; Imran Bhutto; Malia M. Edwards; Manasee Gedam; Rajkumar Baldeosingh; Gerard A. Lutty
TAGS: atrophy, eye, tryptase, minimally conscious state
Invest. Ophthalmol. Vis. Sci.. 2017; 58(13):5887-5896. doi: 10.1167/iovs.17-22989

Includes: Supplemental Content

Retinal Cell Biology November 2017

Phosphodiesterase Inhibitors Sildenafil and Vardenafil Reduce Zebrafish Rod Photoreceptor Outer Segment Shedding

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Leah J. Campbell; Abbie M. Jensen
TAGS: sildenafil, phosphodiesterase inhibitors, adult, larva, rod outer segments, rod photoreceptors, zebrafish, vardenafil
Invest. Ophthalmol. Vis. Sci.. 2017; 58(13):5604-5615. doi: 10.1167/iovs.17-21958

Includes: Supplemental Content

Retinal Cell Biology October 2017

The Transcription Factor Prdm16 Marks a Single Retinal Ganglion Cell Subtype in the Mouse Retina

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Sergio Groman-Lupa; Joseph Adewumi; Ko Uoon Park; Joseph A. Brzezinski IV
TAGS: ganglia, retinal ganglion cells, mice, retina, transcription factor
Invest. Ophthalmol. Vis. Sci.. 2017; 58(12):5421-5433. doi: 10.1167/iovs.17-22442

Retinal Cell Biology October 2017

Increased Indoleamine 2,3-Dioxygenase and Quinolinic Acid Expression in Microglia and Müller Cells of Diabetic Human and Rodent Retina

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Ping Hu; Nicholas H. Hunt; Frank Arfuso; Lynn C. Shaw; Mohammad Nasir Uddin; Meidong Zhu; Raj Devasahayam; Samuel J. Adamson; Vicky L. Benson; Tailoi Chan-Ling; Maria B. Grant
TAGS: diabetes mellitus, diabetes mellitus, type 2, macrophage, microglia, neurons, quinolinic acid, rodentia, tryptophan oxygenase, quinine, retina, entpd1 gene
Invest. Ophthalmol. Vis. Sci.. 2017; 58(12):5043-5055. doi: 10.1167/iovs.17-21654

Retinal Cell Biology October 2017

Inhibition of Placenta Growth Factor Reduces Subretinal Mononuclear Phagocyte Accumulation in Choroidal Neovascularization

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Sergio Crespo-Garcia; Caitlin Corkhill; Christophe Roubeix; Anja-Maria Davids; Norbert Kociok; Olaf Strauss; Antonia M. Joussen; Nadine Reichhart
TAGS: inflammation, placenta growth factor, choroidal neovascularization, lasers, phagocytes, aflibercept
Invest. Ophthalmol. Vis. Sci.. 2017; 58(12):4997-5006. doi: 10.1167/iovs.16-21283

Includes: Supplemental Content

Retinal Cell Biology September 2017

Edaravone Prevents Retinal Degeneration in Adult Mice Following Optic Nerve Injury

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Goichi Akiyama; Yuriko Azuchi; Xiaoli Guo; Takahiko Noro; Atsuko Kimura; Chikako Harada; Kazuhiko Namekata; Takayuki Harada
TAGS: adult, optic nerve injuries, retinal degeneration, mice, edaravone
Invest. Ophthalmol. Vis. Sci.. 2017; 58(11):4908-4914. doi: 10.1167/iovs.17-22250

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Topical Ripasudil Suppresses Retinal Ganglion Cell Death in a Mouse Model of Normal Tension Glaucoma

Photoreceptor Cell–Derived CAPN5 Regulates Retinal Pigment Epithelium Cell Proliferation Through Direct Regulation of SLIT2 Cleavage

Dark Rearing Does Not Prevent Rod Oxidative Stress In Vivo in Pde6b rd10 Mice

Characterization of a Spontaneously Immortalized Murine Müller Glial Cell Line QMMuC-1

Release of Different Cell Mediators During Retinal Pigment Epithelium Regeneration Following Selective Retina Therapy

Metalloproteinase Adamts16 Is Required for Proper Closure of the Optic Fissure

Enteral Arg-Gln Dipeptide Administration Increases Retinal Docosahexaenoic Acid and Neuroprotectin D1 in a Murine Model of Retinopathy of Prematurity

Endocan Blockade Suppresses Experimental Ocular Neovascularization in Mice

Culture Systems of Dissociated Mouse and Human Pluripotent Stem Cell–Derived Retinal Ganglion Cells Purified by Two-Step Immunopanning

Nanosecond Laser Treatment for Age-Related Macular Degeneration Does Not Induce Focal Vision Loss or New Vessel Growth in the Retina

Effect of Anti-C5a Therapy in a Murine Model of Early/Intermediate Dry Age-Related Macular Degeneration

Novel Animal Model of Crumbs-Dependent Progressive Retinal Degeneration That Targets Specific Cone Subtypes

The Role of Angiotensin II/AT1 Receptor Signaling in Regulating Retinal Microglial Activation

Crosstalk Between Histone and DNA Methylation in Regulation of Retinal Matrix Metalloproteinase-9 in Diabetes

Mast Cell-Derived Tryptase in Geographic Atrophy

Phosphodiesterase Inhibitors Sildenafil and Vardenafil Reduce Zebrafish Rod Photoreceptor Outer Segment Shedding

The Transcription Factor Prdm16 Marks a Single Retinal Ganglion Cell Subtype in the Mouse Retina

Increased Indoleamine 2,3-Dioxygenase and Quinolinic Acid Expression in Microglia and Müller Cells of Diabetic Human and Rodent Retina

Inhibition of Placenta Growth Factor Reduces Subretinal Mononuclear Phagocyte Accumulation in Choroidal Neovascularization

Edaravone Prevents Retinal Degeneration in Adult Mice Following Optic Nerve Injury

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Retinal Cell Biology

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