Retinal Cell Biology

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Retinal Cell Biology June 2018

D- cis -Diltiazem Can Produce Oxidative Stress in Healthy Depolarized Rods In Vivo

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Bruce A. Berkowitz; Robert H. Podolsky; Benjamin Farrell; Hojun Lee; Christopher Trepanier; Ali M. Berri; Kristin Dernay; Emma Graffice; Fatema Shafie-Khorassani; Timothy S. Kern; Robin Roberts
TAGS: oxidative stress, diltiazem, magnetic resonance imaging, rod photoreceptors, mice, retina
Invest. Ophthalmol. Vis. Sci.. 2018; 59(7):2999-3010. doi: 10.1167/iovs.18-23829

Retinal Cell Biology June 2018

Characterization of Human iPSC-RPE on a Prosthetic Bruch's Membrane Manufactured From Silk Fibroin

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Chad A. Galloway; Sonal Dalvi; Audra M. A. Shadforth; Shuko Suzuki; Molly Wilson; David Kuai; Ali Hashim; Leslie A. MacDonald; David M. Gamm; Damien G. Harkin; Ruchira Singh
TAGS: biological response modifiers, bruch's basal membrane, fibroins, tissue membrane, proteins, prostheses
Invest. Ophthalmol. Vis. Sci.. 2018; 59(7):2792-2800. doi: 10.1167/iovs.17-23157

Includes: Supplemental Content

Retinal Cell Biology June 2018

Anti-CD160, Alone or in Combination With Bevacizumab, Is a Potent Inhibitor of Ocular Neovascularization in Rabbit and Monkey Models

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Thierry Menguy; Anne Briaux; Elisabeth Jeunesse; Jérôme Giustiniani; Alexandre Calcei; Thierry Guyon; Jacques Mizrahi; Hélène Haegel; Vanessa Duong; Vincent Soler; Pierre Brousset; Armand Bensussan; Isabelle Raymond Letron; Philippe Le Bouteiller
TAGS: vascular endothelial growth factor a, angiogenesis inhibitors, monoclonal antibodies, cercopithecidae, choroidal neovascularization, fibroblast growth factor 2, injection of therapeutic agent, lasers, neovascularization, pathologic, oryctolagus cuniculus, immunoglobulin g, cornea, bevacizumab, transverse spin relaxation rate, anti-vascular endothelial growth factor therapy, coefficient of determination
Invest. Ophthalmol. Vis. Sci.. 2018; 59(7):2687-2698. doi: 10.1167/iovs.18-24024

Includes: Supplemental Content

Retinal Cell Biology May 2018

Transplanted hESC-Derived Retina Organoid Sheets Differentiate, Integrate, and Improve Visual Function in Retinal Degenerate Rats

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Bryce T. McLelland; Bin Lin; Anuradha Mathur; Robert B. Aramant; Biju B. Thomas; Gabriel Nistor; Hans S. Keirstead; Magdalene J. Seiler
TAGS: organoids, photoreceptors, rats, nude, vision, rats, retina, transplantation
Invest. Ophthalmol. Vis. Sci.. 2018; 59(6):2586-2603. doi: 10.1167/iovs.17-23646

Includes: Supplemental Content

Retinal Cell Biology May 2018

Expression Profiling Analysis Reveals Key MicroRNA–mRNA Interactions in Early Retinal Degeneration in Retinitis Pigmentosa

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Ander Anasagasti; Maitane Ezquerra-Inchausti; Olatz Barandika; Maider Muñoz-Culla; María M. Caffarel; David Otaegui; Adolfo López de Munain; Javier Ruiz-Ederra
TAGS: gene expression profiling, retinal degeneration, rna, messenger, micrornas
Invest. Ophthalmol. Vis. Sci.. 2018; 59(6):2381-2392. doi: 10.1167/iovs.18-24091

Includes: Supplemental Content

Retinal Cell Biology May 2018

Young Ossabaw Pigs Fed a Western Diet Exhibit Early Signs of Diabetic Retinopathy

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Rayne R. Lim; DeAna G. Grant; T. Dylan Olver; Jaume Padilla; Alana M. Czajkowski; Teagan R. Schnurbusch; Rajiv R. Mohan; Dean P. Hainsworth; Eric M. Walters; Shyam S. Chaurasia
TAGS: obesity, diabetes mellitus, type 2, diabetic retinopathy, suidae, blood capillaries, retina, diet, western
Invest. Ophthalmol. Vis. Sci.. 2018; 59(6):2325-2338. doi: 10.1167/iovs.17-23616

Retinal Cell Biology May 2018

Cross-Inhibition of Norrin and TGF-β Signaling Modulates Development of Retinal and Choroidal Vasculature

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Roswitha Seitz; Gregor Weber; Sebastian Albrecht; Rudolf Fuchshofer; Ernst R. Tamm; Andreas Ohlmann
TAGS: signal transduction, mice, proteins, retina, vascular network
Invest. Ophthalmol. Vis. Sci.. 2018; 59(6):2240-2251. doi: 10.1167/iovs.17-23403

Retinal Cell Biology May 2018

Differential CXC and CX3C Chemokine Expression Profiles in Aqueous Humor of Patients With Specific Endogenous Uveitic Entities

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Ahmed M. Abu El-Asrar; Nele Berghmans; Saleh A. Al-Obeidan; Priscilla W. Gikandi; Ghislain Opdenakker; Jo Van Damme; Sofie Struyf
TAGS: sarcoidosis, hypertension, chemokines, cx3c chemokines, chemotactic factors, hla-b27 antigen, uveitis, aqueous humor
Invest. Ophthalmol. Vis. Sci.. 2018; 59(6):2222-2228. doi: 10.1167/iovs.17-23225

Retinal Cell Biology April 2018

Topical Ripasudil Suppresses Retinal Ganglion Cell Death in a Mouse Model of Normal Tension Glaucoma

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Kei Akaiwa; Kazuhiko Namekata; Yuriko Azuchi; Hiroki Sano; Xiaoli Guo; Atsuko Kimura; Chikako Harada; Yoshinori Mitamura; Takayuki Harada
TAGS: retinal ganglion cells, mice, glaucoma, normal-tension, neuroprotection
Invest. Ophthalmol. Vis. Sci.. 2018; 59(5):2080-2089. doi: 10.1167/iovs.17-23276

Retinal Cell Biology April 2018

Photoreceptor Cell–Derived CAPN5 Regulates Retinal Pigment Epithelium Cell Proliferation Through Direct Regulation of SLIT2 Cleavage

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Yan Wang; Heming Li; Shihu Zang; Fanfan Li; Yingying Chen; Xiao Zhang; Zongming Song; Qing Peng; Feng Gu
TAGS: western blotting, mutation, cell proliferation, photoreceptors, antibodies, mice, proteins, cytokinesis, regulation, retinal pigment epithelium
Invest. Ophthalmol. Vis. Sci.. 2018; 59(5):1810-1821. doi: 10.1167/iovs.17-22689

Retinal Cell Biology March 2018

Dark Rearing Does Not Prevent Rod Oxidative Stress In Vivo in Pde6b rd10 Mice

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Bruce A. Berkowitz; Robert H. Podolsky; Ali M. Berri; Kristin Dernay; Emma Graffice; Fatema Shafie-Khorassani; Robin Roberts
TAGS: oxidative stress, magnetic resonance imaging, free radicals, rod photoreceptors, superoxides, mice
Invest. Ophthalmol. Vis. Sci.. 2018; 59(3):1659-1665. doi: 10.1167/iovs.17-22734

Retinal Cell Biology March 2018

Characterization of a Spontaneously Immortalized Murine Müller Glial Cell Line QMMuC-1

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Josy Augustine; Sofia Pavlou; Michael O'Hare; Kevin Harkin; Alan Stitt; Tim Curtis; Heping Xu; Mei Chen
TAGS: cytokine, glial fibrillary acidic protein, neuroglia, mice, glutamate
Invest. Ophthalmol. Vis. Sci.. 2018; 59(3):1666-1674. doi: 10.1167/iovs.17-23293

Retinal Cell Biology March 2018

Release of Different Cell Mediators During Retinal Pigment Epithelium Regeneration Following Selective Retina Therapy

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Elisabeth Richert; Stefan Koinzer; Jan Tode; Kerstin Schlott; Ralf Brinkmann; Jost Hillenkamp; Alexa Klettner; Johann Roider
TAGS: cytokine, vascular endothelial growth factor a, biological response modifiers, bodily secretions, cell size, culture media, fluorescent antibody technique, gelatinase a, ki-67 antigen, lasers, matrix metalloproteinases, choroid, retina, titration method, did not receive therapy or drug, retinal pigment epithelium, retinal pigment cell
Invest. Ophthalmol. Vis. Sci.. 2018; 59(3):1323-1331. doi: 10.1167/iovs.17-23163

Retinal Cell Biology March 2018

Metalloproteinase Adamts16 Is Required for Proper Closure of the Optic Fissure

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Mingzhe Cao; Jiamin Ouyang; Jingyi Guo; Siyuan Lin; Shuyi Chen
TAGS: phenotype, immunohistochemistry, basement membrane, bromodeoxyuridine, coloboma, embryo, genes, in situ nick-end labeling, metalloproteases, optics, zebrafish, eye, mice, rna, fissure
Invest. Ophthalmol. Vis. Sci.. 2018; 59(3):1167-1177. doi: 10.1167/iovs.17-22827

Includes: Supplemental Content

Retinal Cell Biology February 2018

Enteral Arg-Gln Dipeptide Administration Increases Retinal Docosahexaenoic Acid and Neuroprotectin D1 in a Murine Model of Retinopathy of Prematurity

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Lynn Calvin Shaw; Sergio Li Calzi; Nan Li; Leni Moldovan; Nilanjana Sengupta-Caballero; Judith Lindsey Quigley; Mircea Ivan; Bokkyoo Jun; Nicolas G. Bazan; Michael Edwin Boulton; Julia Busik; Josef Neu; Maria B. Grant
TAGS: dipeptides, docosahexaenoic acids, neovascularization, pathologic, retinopathy of prematurity, mice, injury of retina
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):858-869. doi: 10.1167/iovs.17-23034

Retinal Cell Biology February 2018

Endocan Blockade Suppresses Experimental Ocular Neovascularization in Mice

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Ting Su; Yisheng Zhong; Anna M. Demetriades; Jikui Shen; Ailing Sui; Yiyun Yao; Yushuo Gao; Yanji Zhu; Xi Shen; Bing Xie
TAGS: angiogenesis, vascular endothelial growth factor a, choroidal neovascularization, neovascularization, pathologic, mice
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):930-939. doi: 10.1167/iovs.17-22945

Includes: Supplemental Content

Retinal Cell Biology February 2018

Culture Systems of Dissociated Mouse and Human Pluripotent Stem Cell–Derived Retinal Ganglion Cells Purified by Two-Step Immunopanning

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Wataru Kobayashi; Akishi Onishi; Hung-Ya Tu; Yuji Takihara; Michiru Matsumura; Kazuko Tsujimoto; Masaru Inatani; Toru Nakazawa; Masayo Takahashi
TAGS: immunohistochemistry, organoids, retinal ganglion cells, mice, retina, stem cells, pluripotent, neuronal outgrowth
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):776-787. doi: 10.1167/iovs.17-22406

Includes: Supplemental Content

Retinal Cell Biology February 2018

Nanosecond Laser Treatment for Age-Related Macular Degeneration Does Not Induce Focal Vision Loss or New Vessel Growth in the Retina

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Kirstan A. Vessey; Tracy Ho; Andrew I. Jobling; Samuel A. Mills; Mai X. Tran; Alice Brandli; Jackson Lam; Robyn H. Guymer; Erica L. Fletcher
TAGS: blindness, lasers, age-related macular degeneration, mice, retina, laser therapy
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):731-745. doi: 10.1167/iovs.17-23098

Retinal Cell Biology February 2018

Effect of Anti-C5a Therapy in a Murine Model of Early/Intermediate Dry Age-Related Macular Degeneration

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Christopher B. Toomey; Michael Landowski; Mikael Klingeborn; Una Kelly; John Deans; Holly Dong; Ons Harrabi; Thomas Van Blarcom; Yik Andy Yeung; Ruslan Grishanin; John C. Lin; Daniel R. Saban; Catherine Bowes Rickman
TAGS: choroidal neovascularization, antibodies, choroid, age-related macular degeneration, mice
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):662-673. doi: 10.1167/iovs.17-23134

Includes: Supplemental Content

Retinal Cell Biology January 2018

Novel Animal Model of Crumbs-Dependent Progressive Retinal Degeneration That Targets Specific Cone Subtypes

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Jinling Fu; Mikiko Nagashima; Chuanyu Guo; Pamela A. Raymond; Xiangyun Wei
TAGS: burkina faso, retinal cone, animal model, photoreceptors, retinal degeneration, rod photoreceptors, ultraviolet rays, zebrafish, proteins, retina
Invest. Ophthalmol. Vis. Sci.. 2018; 59(1):505-518. doi: 10.1167/iovs.17-22572

Includes: Supplemental Content

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D- cis -Diltiazem Can Produce Oxidative Stress in Healthy Depolarized Rods In Vivo

Characterization of Human iPSC-RPE on a Prosthetic Bruch's Membrane Manufactured From Silk Fibroin

Anti-CD160, Alone or in Combination With Bevacizumab, Is a Potent Inhibitor of Ocular Neovascularization in Rabbit and Monkey Models

Transplanted hESC-Derived Retina Organoid Sheets Differentiate, Integrate, and Improve Visual Function in Retinal Degenerate Rats

Expression Profiling Analysis Reveals Key MicroRNA–mRNA Interactions in Early Retinal Degeneration in Retinitis Pigmentosa

Young Ossabaw Pigs Fed a Western Diet Exhibit Early Signs of Diabetic Retinopathy

Cross-Inhibition of Norrin and TGF-β Signaling Modulates Development of Retinal and Choroidal Vasculature

Differential CXC and CX3C Chemokine Expression Profiles in Aqueous Humor of Patients With Specific Endogenous Uveitic Entities

Topical Ripasudil Suppresses Retinal Ganglion Cell Death in a Mouse Model of Normal Tension Glaucoma

Photoreceptor Cell–Derived CAPN5 Regulates Retinal Pigment Epithelium Cell Proliferation Through Direct Regulation of SLIT2 Cleavage

Dark Rearing Does Not Prevent Rod Oxidative Stress In Vivo in Pde6b rd10 Mice

Characterization of a Spontaneously Immortalized Murine Müller Glial Cell Line QMMuC-1

Release of Different Cell Mediators During Retinal Pigment Epithelium Regeneration Following Selective Retina Therapy

Metalloproteinase Adamts16 Is Required for Proper Closure of the Optic Fissure

Enteral Arg-Gln Dipeptide Administration Increases Retinal Docosahexaenoic Acid and Neuroprotectin D1 in a Murine Model of Retinopathy of Prematurity

Endocan Blockade Suppresses Experimental Ocular Neovascularization in Mice

Culture Systems of Dissociated Mouse and Human Pluripotent Stem Cell–Derived Retinal Ganglion Cells Purified by Two-Step Immunopanning

Nanosecond Laser Treatment for Age-Related Macular Degeneration Does Not Induce Focal Vision Loss or New Vessel Growth in the Retina

Effect of Anti-C5a Therapy in a Murine Model of Early/Intermediate Dry Age-Related Macular Degeneration

Novel Animal Model of Crumbs-Dependent Progressive Retinal Degeneration That Targets Specific Cone Subtypes

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Retinal Cell Biology

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