Eye Injuries / Ocular Trauma

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Cornea April 2018

Tetramethylpyrazine in a Murine Alkali-Burn Model Blocks NFκB/NRF-1/CXCR4-Signaling-Induced Corneal Neovascularization

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Mingjun Tang; Ying Yang; Jingzhi Yu; Jin Qiu; Pei Chen; Yihui Wu; Qiyun Wang; Zhuojun Xu; Jian Ge; Keming Yu; Jing Zhuang
TAGS: alkalies, burns, choroidal neovascularization, corneal neovascularization, cxcr4 receptors, mice
Invest. Ophthalmol. Vis. Sci.. 2018; 59(5):2133-2141. doi: 10.1167/iovs.17-23712

Includes: Supplemental Content

Retinal Cell Biology February 2018

Enteral Arg-Gln Dipeptide Administration Increases Retinal Docosahexaenoic Acid and Neuroprotectin D1 in a Murine Model of Retinopathy of Prematurity

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Lynn Calvin Shaw; Sergio Li Calzi; Nan Li; Leni Moldovan; Nilanjana Sengupta-Caballero; Judith Lindsey Quigley; Mircea Ivan; Bokkyoo Jun; Nicolas G. Bazan; Michael Edwin Boulton; Julia Busik; Josef Neu; Maria B. Grant
TAGS: dipeptides, docosahexaenoic acids, neovascularization, pathologic, retinopathy of prematurity, mice, injury of retina
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):858-869. doi: 10.1167/iovs.17-23034

Glaucoma December 2017

AAV2-Mediated Transduction of the Mouse Retina After Optic Nerve Injury

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Robert W. Nickells; Heather M. Schmitt; Margaret E. Maes; Cassandra L. Schlamp
TAGS: optic nerve injuries, eye, mice, optic nerve, retina
Invest. Ophthalmol. Vis. Sci.. 2017; 58(14):6091-6104. doi: 10.1167/iovs.17-22634

Includes: Supplemental Content

Retinal Cell Biology September 2017

Edaravone Prevents Retinal Degeneration in Adult Mice Following Optic Nerve Injury

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Goichi Akiyama; Yuriko Azuchi; Xiaoli Guo; Takahiko Noro; Atsuko Kimura; Chikako Harada; Kazuhiko Namekata; Takayuki Harada
TAGS: adult, optic nerve injuries, retinal degeneration, mice, edaravone
Invest. Ophthalmol. Vis. Sci.. 2017; 58(11):4908-4914. doi: 10.1167/iovs.17-22250

Retina September 2017

Comparison of Continuous-Wave and Micropulse Modulation in Retinal Laser Therapy

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Jenny Wang; Yi Quan; Roopa Dalal; Daniel Palanker
TAGS: computer simulation, lasers, oryctolagus cuniculus, body tissue, choroid, retina, laser therapy
Invest. Ophthalmol. Vis. Sci.. 2017; 58(11):4722-4732. doi: 10.1167/iovs.17-21610

Includes: Multimedia, Supplemental Content

Cornea September 2017

Hyaluronan Rich Microenvironment in the Limbal Stem Cell Niche Regulates Limbal Stem Cell Differentiation

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Tarsis F. Gesteira; Mingxia Sun; Yvette M. Coulson-Thomas; Yu Yamaguchi; Lung-Kun Yeh; Vincent Hascall; Vivien J. Coulson-Thomas
TAGS: debridement, stem cells, epithelium, alkalies, burns, wounds and injuries, cornea, mice, epithelial cells, hyaluronan, stem cell niche
Invest. Ophthalmol. Vis. Sci.. 2017; 58(11):4407-4421. doi: 10.1167/iovs.17-22326

Includes: Supplemental Content

Cornea July 2017

Retinoic Acid Engineered Amniotic Membrane Used as Graft or Homogenate: Positive Effects on Corneal Alkali Burns

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Romain Joubert; Estelle Daniel; Nicolas Bonnin; Aurélie Comptour; Christelle Gross; Corinne Belville; Frédéric Chiambaretta; Loïc Blanchon; Vincent Sapin
TAGS: ulcer, alkalies, amnion, burns, tissue transplants, tretinoin, cornea, corneal burn
Invest. Ophthalmol. Vis. Sci.. 2017; 58(9):3513-3518. doi: 10.1167/iovs.17-21810

Includes: Supplemental Content

Cornea March 2017

Topical Cryopreserved Amniotic Membrane and Umbilical Cord Eye Drops Promote Re-Epithelialization in a Murine Corneal Abrasion Model

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Sean Tighe; Hamid-Reza Moein; Lorraine Chua; Anny Cheng; Pedram Hamrah; Scheffer C. G. Tseng
TAGS: corneal abrasion, epithelium, amnion, cryopreservation, umbilical cord, cornea, mice, eyedrops, epithelialization, abrasion
Invest. Ophthalmol. Vis. Sci.. 2017; 58(3):1586-1593. doi: 10.1167/iovs.16-20834

Cornea January 2017

Sustained Subconjunctival Delivery of Infliximab Protects the Cornea and Retina Following Alkali Burn to the Eye

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Chengxin Zhou; Marie-Claude Robert; Vassiliki Kapoulea; Fengyang Lei; Anna M. Stagner; Frederick A. Jakobiec; Claes H. Dohlman; Eleftherios I. Paschalis
TAGS: tumor necrosis factors, alkalies, burns, oryctolagus cuniculus, cornea, eye, retina, infliximab, subconjunctival route
Invest. Ophthalmol. Vis. Sci.. 2017; 58(1):96-105. doi: 10.1167/iovs.16-20339

Includes: Supplemental Content

Retina August 2016

Sildenafil Improves Functional and Structural Outcome of Retinal Injury Following Term Neonatal Hypoxia-Ischemia

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Suna Jung; Aaron Johnstone; Zehra Khoja; Emmanouil Rampakakis; Pierre Lachapelle; Pia Wintermark
TAGS: ischemia, sildenafil, hypoxia, newborn, retina, injury of retina
Invest. Ophthalmol. Vis. Sci.. 2016; 57(10):4306-4314. doi: 10.1167/iovs.16-19385

Nantotechnology and Regenerative Medicine June 2016

Dexamethasone Drug Eluting Nanowafers Control Inflammation in Alkali-Burned Corneas Associated With Dry Eye

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Fang Bian; Crystal S. Shin; Changjun Wang; Stephen C. Pflugfelder; Ghanashyam Acharya; Cintia S. De Paiva
TAGS: inflammation, dexamethasone, alkalies, burns, dry eye syndromes, eye burns, cornea, mice, stress, eye inflammation
Invest. Ophthalmol. Vis. Sci.. 2016; 57(7):3222-3230. doi: 10.1167/iovs.16-19074

Retinal Cell Biology April 2016

Antiviral Drug Ganciclovir Is a Potent Inhibitor of the Proliferation of Müller Glia–Derived Progenitors During Zebrafish Retinal Regeneration

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Shuqiang Zhang; Zhaoxia Mu; Chunjiao He; Minmin Zhou; Dong Liu; Xiao-Feng Zhao; Daniel Goldman; Hui Xu
TAGS: anaplasia, antiviral agents, bromodeoxyuridine, fluorescent antibody technique, ganciclovir, microglia, neuroglia, wounds and injuries, zebrafish, eye, retina, injury of retina, painful bladder syndrome
Invest. Ophthalmol. Vis. Sci.. 2016; 57(4):1991-2000. doi: 10.1167/iovs.15-18669

Includes: Supplemental Content

Retinal Cell Biology April 2016

A Targeted Inhibitor of the Alternative Complement Pathway Accelerates Recovery From Smoke-Induced Ocular Injury

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Alex Woodell; Bryan W. Jones; Tucker Williamson; Gloriane Schnabolk; Stephen Tomlinson; Carl Atkinson; Bärbel Rohrer
TAGS: familial hypercholesterolemia, biological response modifiers, complement pathway, alternative, eye injuries, recovery of function, smoke, mice, family history
Invest. Ophthalmol. Vis. Sci.. 2016; 57(4):1728-1737. doi: 10.1167/iovs.15-18471

Cornea December 2015

VesselJ: A New Tool for Semiautomatic Measurement of Corneal Neovascularization

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Alessandro Rabiolo; Fabio Bignami; Paolo Rama; Giulio Ferrari
TAGS: alkalies, burns, choroidal neovascularization, corneal neovascularization, sutures, cornea, lymphatic vessel, copy number polymorphism
Invest. Ophthalmol. Vis. Sci.. 2015; 56(13):8199-8206. doi: 10.1167/iovs.15-17098

Includes: Multimedia, Supplemental Content

Cornea September 2015

Inhibition of Lymphangiogenesis and Hemangiogenesis in Corneal Inflammation by Subconjunctival Prox1 siRNA Injection in Rats

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Chang Rae Rho; Jun-Sub Choi; Minkoo Seo; Suk Kyeong Lee; Choun-Ki Joo
TAGS: alkalies, burns, injection of therapeutic agent, keratitis, cornea, rats, rna, small interfering, lymphangiogenesis
Invest. Ophthalmol. Vis. Sci.. 2015; 56(10):5871-5879. doi: 10.1167/iovs.14-14433

Includes: Supplemental Content

Retina August 2015

Visual Impairments Following Term Neonatal Encephalopathy: Do Retinal Impairments Also Play a Role?

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Suna Jung; Anna Polosa; Pierre Lachapelle; Pia Wintermark
TAGS: ischemia, hypoxia, traumatic brain injuries, electroretinography, newborn, ligation, visual impairment, brain, eye, retina, neonatal encephalopathy, injury of retina
Invest. Ophthalmol. Vis. Sci.. 2015; 56(9):5182-5193. doi: 10.1167/iovs.15-16407

Cornea July 2015

Desiccating Stress-Induced MMP Production and Activity Worsens Wound Healing in Alkali-Burned Corneas

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Fang Bian; Flavia S. A. Pelegrino; Stephen C. Pflugfelder; Eugene A. Volpe; De-Quan Li; Cintia S. de Paiva
TAGS: alkalies, burns, dry eye syndromes, gelatinase b, matrix metalloproteinases, wound healing, wounds and injuries, cornea, stress
Invest. Ophthalmol. Vis. Sci.. 2015; 56(8):4908-4918. doi: 10.1167/iovs.15-16631

Retina July 2015

Transient Downregulation of Melanopsin Expression After Retrograde Tracing or Optic Nerve Injury in Adult Rats

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Francisco M. Nadal-Nicolás; Maria H. Madeira; Manuel Salinas-Navarro; Manuel Jiménez-López; Caridad Galindo-Romero; Arturo Ortín-Martínez; Ana Raquel Santiago; Manuel Vidal-Sanz; Marta Agudo-Barriuso
TAGS: albinism, axotomy, down-regulation, optic nerve injuries, spinal cord injuries, rats, retina, melanopsin
Invest. Ophthalmol. Vis. Sci.. 2015; 56(8):4309-4323. doi: 10.1167/iovs.15-16963

Letters to the Editor June 2015

Paravascular Pathways in the Eye: Is There an ‘Ocular Glymphatic System'?

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Alastair K. Denniston; Pearse A. Keane
TAGS: eye
Invest. Ophthalmol. Vis. Sci.. 2015; 56(6):3955-3956. doi: 10.1167/iovs.15-17243

Multidisciplinary Ophthalmic Imaging June 2015

In Vivo Evaluation of White Matter Integrity and Anterograde Transport in Visual System After Excitotoxic Retinal Injury With Multimodal MRI and OCT

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Leon C. Ho; Bo Wang; Ian P. Conner; Yolandi van der Merwe; Richard A. Bilonick; Seong-Gi Kim; Ed X. Wu; Ian A. Sigal; Gadi Wollstein; Joel S. Schuman; Kevin C. Chan
TAGS: magnetic resonance imaging, biological transport, n-methylaspartate, visual pathways, wounds and injuries, brain, eye, mice, optic nerve, normal saline, optic tract, visual system, injury of retina, white matter, saline solution, personal integrity
Invest. Ophthalmol. Vis. Sci.. 2015; 56(6):3788-3800. doi: 10.1167/iovs.14-15552

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Tetramethylpyrazine in a Murine Alkali-Burn Model Blocks NFκB/NRF-1/CXCR4-Signaling-Induced Corneal Neovascularization

Enteral Arg-Gln Dipeptide Administration Increases Retinal Docosahexaenoic Acid and Neuroprotectin D1 in a Murine Model of Retinopathy of Prematurity

AAV2-Mediated Transduction of the Mouse Retina After Optic Nerve Injury

Edaravone Prevents Retinal Degeneration in Adult Mice Following Optic Nerve Injury

Comparison of Continuous-Wave and Micropulse Modulation in Retinal Laser Therapy

Hyaluronan Rich Microenvironment in the Limbal Stem Cell Niche Regulates Limbal Stem Cell Differentiation

Retinoic Acid Engineered Amniotic Membrane Used as Graft or Homogenate: Positive Effects on Corneal Alkali Burns

Topical Cryopreserved Amniotic Membrane and Umbilical Cord Eye Drops Promote Re-Epithelialization in a Murine Corneal Abrasion Model

Sustained Subconjunctival Delivery of Infliximab Protects the Cornea and Retina Following Alkali Burn to the Eye

Sildenafil Improves Functional and Structural Outcome of Retinal Injury Following Term Neonatal Hypoxia-Ischemia

Dexamethasone Drug Eluting Nanowafers Control Inflammation in Alkali-Burned Corneas Associated With Dry Eye

Antiviral Drug Ganciclovir Is a Potent Inhibitor of the Proliferation of Müller Glia–Derived Progenitors During Zebrafish Retinal Regeneration

A Targeted Inhibitor of the Alternative Complement Pathway Accelerates Recovery From Smoke-Induced Ocular Injury

VesselJ: A New Tool for Semiautomatic Measurement of Corneal Neovascularization

Inhibition of Lymphangiogenesis and Hemangiogenesis in Corneal Inflammation by Subconjunctival Prox1 siRNA Injection in Rats

Visual Impairments Following Term Neonatal Encephalopathy: Do Retinal Impairments Also Play a Role?

Desiccating Stress-Induced MMP Production and Activity Worsens Wound Healing in Alkali-Burned Corneas

Transient Downregulation of Melanopsin Expression After Retrograde Tracing or Optic Nerve Injury in Adult Rats

Paravascular Pathways in the Eye: Is There an ‘Ocular Glymphatic System'?

In Vivo Evaluation of White Matter Integrity and Anterograde Transport in Visual System After Excitotoxic Retinal Injury With Multimodal MRI and OCT

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